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All times listed are Central Daylight Time. Program and Faculty are updated often – check back for the most up-to-date information. Click on session name to view session description and component talks.

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Sunday, Oct 26th
9:00 AM - 10:00 AM Central Time
26S07: Energizing Immunity: How Mitochondria Contribute to Inflammation in Lupus and Photosensitivity
Location: S105
Moderator: Christian Lood, PhD – University of Washington
Moderator: Richard Moore, BSc (he/him/his) – Cedars-Sinai
Session Coordinator: Christian Lood, PhD – University of Washington
CE: 1.00
Sunday, Oct 26th
9:00 AM - 9:30 AM Central Time
Ultraviolet-Mediated Damage to Mitochondria in Systemic Lupus Erythematosus
Location: S105
Speaker: J. Michelle Kahlenberg, MD, PhD – University of Michigan
Sunday, Oct 26th
9:30 AM - 10:00 AM Central Time
Erythrocytes Carrying More Power Than Expected
Location: S105
Speaker: Simone Caielli, PhD – Weill Cornell Medicine
Sunday, Oct 26th
10:30 AM - 11:30 AM Central Time
26S26: Trisomy 21 and Immune Dysregulation: Bridging Research and Clinical Practice
Location: W471B
Moderator: Pui Lee, MD, PhD – Boston Children's Hospital
Moderator: Daniel Ibanez, MD – University of Miami
Session Coordinator: Pui Lee, MD, PhD – Boston Children's Hospital
CE: 1.00
Sunday, Oct 26th
10:30 AM - 11:00 AM Central Time
Defining the Immune Landscape Associated with Trisomy 21
Location: W471B
Speaker: Dusan Bogunovic, PhD – Columbia University Medical Center
Sunday, Oct 26th
11:00 AM - 11:30 AM Central Time
Modulating the Immune System in the Clinical Care of Down's Syndrome
Location: W471B
Speaker: Jessica Bloom, MD, MS – University of Colorado
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
B Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster I
Location: Hall F1
CE: 0.00
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0018: Development of a noval ‘1+1+1’ CD19- and BCMA-dual targeted T cell engager for autoimmune diseases
Location: Hall F1
Abstract Poster Presenter: Zhenping Zhu, n/a – Helixon Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0013: Discovery and Characterization of SIM0710, a Novel B and T Lymphocyte Attenuator (BTLA) Agonistic Antibody for Autoimmune/Inflammatory Diseases
Location: Hall F1
Abstract Poster Presenter: Minyun Zhou, PhD – Simcere Pharmaceutical Group
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0016: Pharmacology Analyses of Sail’s In Vivo hCD19 CAR-T Product Reveal Mechanistic Insights Underlying its Optimal Dose Efficiency Profile in Both Healthy Donors and SLE Patient Samples
Location: Hall F1
Abstract Poster Presenter: Siobhan Rice, PhD – Sail Biomedicines
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0015: CDR111 is a novel CD19 and BCMA dual-targeting T cell engager (TCE) for the treatment of severe and refractory autoimmune diseases
Location: Hall F1
Abstract Poster Presenter: Philipp Richle, -None- – CDR-Life
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0010: XmAb657, a CD19 x CD3 T-Cell Engaging Bispecific Antibody for Autoimmune Disease
Location: Hall F1
Abstract Poster Presenter: Matthew Bernett, PhD – Xencor, Inc.
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0014: NKX019, an allogeneic off-the-shelf CD19 targeting CAR-NK cell therapy, induces deep CD19+ B cell depletion in hematological malignancy and models of autoimmune disease
Location: Hall F1
Abstract Poster Presenter: Mira Tohmé, PhD – nkarta therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0006: QEL-005: CD19 CAR-Regulatory T cell therapy, a novel approach for the treatment of complex immune mediated inflammatory diseases including Rheumatoid Arthritis and Systemic Sclerosis
Location: Hall F1
Abstract Poster Presenter: Jenny McGovern, PhD – Quell Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0009: MRT-6160, a VAV1-Directed Molecular Glue Degrader, Attenuates T and B Cell Effector Functions and Inhibits Disease Progression in a Spontaneous MRL-Fas^lpr Mouse Model
Location: Hall F1
Abstract Poster Presenter: Marisa Peluso, MS – Monte Rosa Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0002: KITE-363: An Autologous Anti-CD19/CD20 CAR-T Product for the Treatment of Autoimmune Rheumatic Diseases
Location: Hall F1
Abstract Poster Presenter: Brian Kim, MS – Kite, a Gilead Company
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0003: In Vivo Generation of anti-CD19 CAR T Cells Utilizing Circular RNA Encapsulated in Targeted Lipid Nanoparticles
Location: Hall F1
Abstract Poster Presenter: Edo Kon, PhD, MBA (he/him/his) – RiboX Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0005: LBL-047, A First-In-Class Anti-BDCA2/TACI Fusion Protein, Inhibits the Function of Both pDCs and B cells
Location: Hall F1
Abstract Poster Presenter: Hong Ling, n/a – Nanjing Leads Biolabs Co., Ltd.
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0011: KT502, a novel CD19-directed TCE (T-cell engager), leads to rapid and deep B-cell depletion with low cytokine release
Location: Hall F1
Abstract Poster Presenter: Min Bao, MD – Kali Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0012: KT501, a CD19/BCMA/CD3 trispecific antibody, leads to rapid and deep B-cell depletion with well-tolerated safety
Location: Hall F1
Abstract Poster Presenter: Min Bao, MD – Kali Therapeutics
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0001: ATG-201, a Novel Steric Hindrance-based Masking CD19xCD3 T-cell Engager (TCE) for the Treatment of B Cell-related Autoimmune Diseases
Location: Hall F1
Abstract Poster Presenter: Bing Hou, PhD – Antengene. Corp.
Sunday, Oct 26th
10:30 AM - 12:30 PM Central Time
0008: Characterization of S-1117, a novel pan-IgG protease engineered for reduced immunogenicity using the IMPACT platform
Location: Hall F1
Abstract Poster Presenter: Julia Manasson, MD, MS – Seismic Therapeutic
Monday, Oct 27th
8:30 AM - 9:30 AM Central Time
27M05: Flushing the Joint: Using Lymphatic Drainage to Control Synovial Inflammation
Location: W181A-C
Moderator: Richard Bell, PhD – Hospital for Special Surgery
Moderator: Xi Lin, PhD – University of Rochester Medical Center
Session Coordinator: Theresa Lu, MD;PhD – Hospital for Special Surgery
CE: 1.00
Monday, Oct 27th
8:30 AM - 9:30 AM Central Time
The Synovial Lymphatic System and its Dysfunction in Arthritic Progression
Location: W181A-C
Speaker: Edward Schwarz, PhD – University of Rochester, Rochester, NY, USA
Monday, Oct 27th
10:00 AM - 11:30 AM Central Time
27M16: Abstracts: T Cell Biology & Targets in Autoimmune & Inflammatory Disease
Location: W183A-C
Abstract Moderator: Jose Crispin, MD, PhD – Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Abstract Moderator: Jason Weinstein, PhD – Rutgers New Jersey Medical School
CE: 0.00
Monday, Oct 27th
10:00 AM - 10:15 AM Central Time
0885: MAIT cell-mediated immune modulation in lupus: antigen-driven expansion as a protective strategy
Location: W183A-C
Presenting Author: Sladjana Skopelja-Gardner, PhD – Dartmouth Geisel School of Medicine
Monday, Oct 27th
10:15 AM - 10:30 AM Central Time
0886: A First-in-class Biologic Selectively Targeting hla-b27-reactive T Cells in Ankylosing Spondylitis
Location: W183A-C
Presenting Author: Patrick Holec, PhD – Fletcher Biosciences
Monday, Oct 27th
10:30 AM - 10:45 AM Central Time
0887: Dynamics of cytotoxic and regulatory CD8 T cells underlies outcome in ICI-myotoxicity
Location: W183A-C
Presenting Author: Runci Wang, MD, PhD (she/her/hers) – Renji Hospital, Shanghai Jiaotong University
Monday, Oct 27th
10:45 AM - 11:00 AM Central Time
0888: TargetScan Platform Identifies Targets of CD8+ T cells in Ankylosing Spondylitis and Birdshot Uveitis
Location: W183A-C
Presenting Author: Andrew Ferretti, PhD – TScan Therapeutics
Monday, Oct 27th
11:00 AM - 11:15 AM Central Time
0889: Potentially pathogenic memory CD4 T cells with a B cell helper phenotype expand in ACPA+ individuals during progression to rheumatoid arthritis
Location: W183A-C
Presenting Author: Ziyuan He, PhD – Allen Institute for Immunology
Monday, Oct 27th
11:15 AM - 11:30 AM Central Time
0890: Granzyme K+ CD8 T cells colocalize with myeloid cells and activate them through several pathways
Location: W183A-C
Presenting Author: Anna Helena Jonsson, MD, PhD – University of Colorado
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
B Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster II
Location: Hall F1
CE: 0.00
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
Innate Immunity Poster
Location: Hall F1
CE: 0.00
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
T Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster
Location: Hall F1
CE: 0.00
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0978: IL-17A+ HLA-DR-CCR6+ regulatory T cells: Dual role in T cell suppression and synovial inflammation in arthritis.
Location: Hall F1
Abstract Poster Presenter: Bennie Heeswijk, MSc (he/him/his) – Erasmus University Medical Center, Rotterdam, the Netherlands
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0979: IL-23 upregulates IFN-γ secretion in Th17.1, but not in Th17 or classical Th1 cells
Location: Hall F1
Abstract Poster Presenter: Bennie van Heeswijk, MSc (he/him/his) – Erasmus MC, University Medical Center Rotterdam
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0980: Expansion of Viral-Reactive CD8+ T cell Repertoire Stratified by Pathotype in New-onset ACPA+ Rheumatoid Arthritis
Location: Hall F1
Abstract Poster Presenter: Carl Coyle, PhD – King's College London
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0981: GNTI-350: A CAR-Treg Therapy Offering Durable Immune Reset with Improved Safety for B Cell–Driven Autoimmune Diseases
Location: Hall F1
Abstract Poster Presenter: Christopher Moore, PhD – GentiBio
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0982: Impact of Immunosuppressive Therapies on Shingrix Vaccine Response in Immune-Mediated Inflammatory Diseases
Location: Hall F1
Abstract Poster Presenter: Cristiana Sieiro Santos, MD – Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0983: Detecting Autoreactive CD4+ T Cells Relevant to Mixed Connective Tissue Disease
Location: Hall F1
Abstract Poster Presenter: Grace Frechette, BS – Creighton University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0984: Interleukin-21 as a driver of CD8 T cell tissue resident memory and pathogenesis in dermatomyositis
Location: Hall F1
Abstract Poster Presenter: Heather Ren, MD, PhD – Children's Hospital of Pittsburgh
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0985: Lupus Skin Shapes a Distinct Inflammatory Milieu that Drives the Skewing of Treg and inflammatory T cells
Location: Hall F1
Abstract Poster Presenter: Hiroshi Kato, MD (he/him/his) – Michigan Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0986: LBL-053, A Novel Anti-TL1A/p40 Bispecific Antibody for the Treatment of Autoimmune Disorders.
Location: Hall F1
Abstract Poster Presenter: Hong Ling, n/a – Nanjing Leads Biolabs Co., Ltd.
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0987: S-4321, a novel dual-cell bifunctional PD-1:FcγRIIb selective agonist antibody for autoimmune disease, maintains expression of PD-1 on target cells and enhances inhibitory receptor expression on T cells in vivo
Location: Hall F1
Abstract Poster Presenter: Julia Manasson, MD, MS – Seismic Therapeutic
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0988: Distinct Effects of Inhibitory Receptor Agonism on RA Synovial CD4+ T Cell Functions
Location: Hall F1
Abstract Poster Presenter: Kazuhiko Higashioka, MD, PhD – Brigham and Women's Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0989: Human MAIT cell produce IL-17 independently of IL-23 and TL1A
Location: Hall F1
Abstract Poster Presenter: Kevin Hsu, PhD – AstraZeneca
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0990: An Fc-engineered Agonistic anti-pd-1 Antibody Selectively Depletes pd-1⁺ Cells and Attenuates T Cell Activation in vitro and in vivo in a Xenogeneic Graft-versus-host Disease (GvHD) Model
Location: Hall F1
Abstract Poster Presenter: Laetitia POUZOL, PhD, PharmD (she/her/hers) – Anaveon
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0991: MTHFD2 is a Novel Metabolic Target in Autoimmune Disease
Location: Hall F1
Abstract Poster Presenter: Laura McMillan – Sitryx Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0992: FoxP3^Lo CD4⁺ T cells are functionally suppressive and expanded in the immune-mediated fibrotic diseases IgG4-related disease and systemic sclerosis
Location: Hall F1
Abstract Poster Presenter: Laura Yockey, MD, PhD – MGH
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0993: NOD2 mutations mediate IL-17 predisposition in patients with Blau syndrome
Location: Hall F1
Abstract Poster Presenter: Leah Huey, BS – Oregon Health & Science University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0994: UTAA91: An Off-the-Shelf Allogeneic CAR-Vδ1T Therapy Leveraging CD19 Nanoantibody for B-cell Depletion and PD-1 Agonist Nanoantibody for Pathogenic T-cell Elimination in Refractory Autoimmune Diseases
Location: Hall F1
Abstract Poster Presenter: Lin Yang, PhD – PersonGen BioTherapeutics(Suzhou) Co., Ltd., Suzhou, China; PersonGenAnke Cellular Therapeutics Co., Ltd.,Hefei, China; Cyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0995: Resident Memory T Cells Stimulate Pathogenic Activity in Fibroblast-like Synoviocytes
Location: Hall F1
Abstract Poster Presenter: Madison Mangin, BS – Boston Children's Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0996: Breaking Inflammatory Pathways: ELN28, a Novel Dual TNFα/JAK Inhibitor Drug Conjugate for Chronic Inflammation
Location: Hall F1
Abstract Poster Presenter: Obinna Ubah, PhD – Elasmogen Limited
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0997: Identification of Novel HLA Class II–Restricted Autoantigens in Scleroderma and Ulcerative Colitis Using TargetScan 
Location: Hall F1
Abstract Poster Presenter: Olivia Pryor, n/a – TScan Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0998: Preclinical Characterization of a Novel Bi-specific Antibody Targeting IL-23p19 and IL-36R for The Treatment of Autoimmune Diseases
Location: Hall F1
Abstract Poster Presenter: Qianqian Yin, PhD (she/her/hers) – Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0999: Myositis Induced by Histidyl-Transfer tRNA Synthetase is Exacerbated by Membranopathy and Suppressed by Regulatory T Cells
Location: Hall F1
Abstract Poster Presenter: Samantha Coss, MD, PhD (she/her/hers) – Nationwide Children's Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1000: A Deep-learning Based Approach Uncovers Novel Mediators of Micro-rna Restraint of type-2 Immunity
Location: Hall F1
Abstract Poster Presenter: Shaan Sekhon, BA – CNU College of Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1001: LBL-057, a Novel ADCC Enhanced PD-1 Agonist VHH-Fc Antibody
Location: Hall F1
Abstract Poster Presenter: Xiao Huang, MS – Leads Biolabs
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1002: ATF3 Inhibits Pulmonary Fibrosis via CD4+CD25−LAG3+ T Cells
Location: Hall F1
Abstract Poster Presenter: Xiao Zhang, n/a – The Eighth Affiliated Hospital of Sun Yat-sen University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1003: Potent Engineering of Polyfunctional CD8+ T Cells by a Novel In Vivo CAR mRNA Product Candidate (CPTX2309) in a Targeted Lipid Nanoparticle (tLNP) Utilizing CellSeeker^TM Technology
Location: Hall F1
Abstract Poster Presenter: Yan Zhang, PhD – Capstan Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1004: Single-Cell Analysis Reveals Tissue Resident Memory T Cells Heterogeneity in the Joint
Location: Hall F1
Abstract Poster Presenter: Yang Yang, PhD – Boston Children's Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1005: CD49a Contributes to Binding and Survival of Synovial Resident Memory T cells
Location: Hall F1
Abstract Poster Presenter: Yusuke Miyashita, MD, PhD (he/him/his) – Boston Children's Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
1006: Ai-guided Generation and Preclinical Evaluation of an OX40L-IL31 Bispecific Antibody
Location: Hall F1
Abstract Poster Presenter: Zhenping Zhu, n/a – Helixon Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0914: Preclinical Expansion of Autoreactive Naive B cells Drives RA onset in ACPA+ individuals
Location: Hall F1
Abstract Poster Presenter: Xiaohao Wu, PhD – Stanford University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0926: Discovery and Characterization of SIM0711: a Potent and Selective IRAK4 PROTAC with Improved Efficacy and Safety
Location: Hall F1
Abstract Poster Presenter: Minyun Zhou, PhD – Simcere Pharmaceutical Group
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0899: Altered B Cell Subsets Shared in Immune Checkpoint Inhibitor Associated Sicca Syndrome and Sjogren's Disease
Location: Hall F1
Abstract Poster Presenter: Caroline Atlas, MD (she/her/hers) – Columbia University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0924: Human Serum Albumin Co-Modified with Malondialdehyde-Acetaldehyde and Citrulline Bind Multiple Scavenger Receptors and Alter Cellular Morphology
Location: Hall F1
Abstract Poster Presenter: Lauren Klingemann, BS – University of Nebraska Medical Center
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0911: A Novel Fcrn × Albumin Bispecific Antibody Demonstrates Extended Half-life And deep Igg Reduction in Preclinical Mouse Models
Location: Hall F1
Abstract Poster Presenter: Quan Yu, PhD – Ailux
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0920: Functional Characterization of NEMO-NDAS Causing Variants in Patients’ PBMCs and in Wildtype and Mutant U937 Cells
Location: Hall F1
Abstract Poster Presenter: Elizabeth Morgan, BS – Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0901: Data-Driven Metabolomics Identifies Diagnostic Signatures and Patient Subgroups in Systemic Autoimmune Disorders
Location: Hall F1
Abstract Poster Presenter: Chary Lopez-Pedrera, PhD – IMIBIC - Reina Sofia Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0929: SP2H, a Targeted Degrader of STimulator of INterferon Genes (STING), selectively inhibits STING-driven inflammation in vitro and in vivo and improves survival in Trex1^-/- mice
Location: Hall F1
Abstract Poster Presenter: Richard BETHELL, PhD, MA (he/him/his) – Sulis Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0897: APECED Disease Reorganizes the B Cell Compartment Toward Alternatively Activated Subsets
Location: Hall F1
Abstract Poster Presenter: Andre Limnander, PhD – Regeneron
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0916: UVB-Irradiated Keratinocyte Extracellular Vesicles Trigger Innate Immune Activation via Type I Interferons and STING Pathway
Location: Hall F1
Abstract Poster Presenter: Ahmed Eldaboush, MD – University of Pennsylvania
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0898: Distinct B Cell and Plasma Cell Immunosuppression Strategies Eliminate Antigen-Specific Cells of the B Lineage
Location: Hall F1
Abstract Poster Presenter: Carley Tasker, PhD – Regeneron Pharmaceuticals
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0922: Phenotypic and Transcriptomic Divergence in C3 Glomerular Mouse Models: Insights into Immune and Sex Correlates
Location: Hall F1
Abstract Poster Presenter: Juan Liang, DrPH – Gempharmatech
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0913: Potent and Selective Oral IRF5 Degrader, KT-579, Demonstrates In Vitro and In Vivo Activity Comparable or Superior to Approved or Clinically Active Agents in Human Cellular Assays and Lupus Efficacy Models
Location: Hall F1
Abstract Poster Presenter: Veronica Campbell, BSc – Kymera Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0923: Influenza Virus Infection Alters the MHC Class II Self-Immunopeptidome to Present Lupus-Associated Autoantigens
Location: Hall F1
Abstract Poster Presenter: Julia Rood, MD, PhD – Children's Hospital of Philadelphia
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0909: Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice.
Location: Hall F1
Abstract Poster Presenter: Marcus Hines, MD;PhD – New York University Grossman School of Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0927: Improved Skin Lymphatic Flow Regulates Dendritic Cells to Mediate Lymph Node Fibroblast Alterations and Immune Responses in Lupus
Location: Hall F1
Abstract Poster Presenter: Mir Howlader, BA – Weill Cornell Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0903: Ianalumab‘s dual mode of action: targeting B cells through enhanced B cell depletion and blockade of B cell-activating factor receptor signaling
Location: Hall F1
Abstract Poster Presenter: Isabelle Isnardi, PhD – Novartis
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0931: Reduced mitophagy in salivary glands of Sjögren's disease patients is associated with mitochondrial structural damage
Location: Hall F1
Abstract Poster Presenter: Sergio Aguilera, MD – Clinica Indisa
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0908: E-602 (Efgitasialase alfa) Enhances Memory B Cell Depletion and Reduces Profibrotic Macrophages via Desialylation in Autoimmune Disease
Location: Hall F1
Abstract Poster Presenter: Li Peng, PhD – Palleon Pharmaceuticals
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0933: Spatial Transcriptomics Reveal Altered Immune Dynamics Regulating Placental Development In a Humanized-TLR8 Mouse Model of Spontaneous Anti-Phospholipid Antibody Induced Pregnancy Loss
Location: Hall F1
Abstract Poster Presenter: Yunwei Xia, BA – Feinstein Institutes for Medical Research
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0902: A Novel Approach to Study ANA+ B Cells in Lupus Integrating Flow Cytometry with Single-cell Culture
Location: Hall F1
Abstract Poster Presenter: Muriel Velez Arteaga, MD (she/her/hers) – The Elmezzi School of Molecular Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0906: Preclinical Characterization of IBI3034, an TACI and BCMA Chimeric Fc Fusion Protein, that Potently Modulates B Lymphocytes and Serum Immunoglobulin for the Treatment of B cell Related Autoimmune Disease
Location: Hall F1
Abstract Poster Presenter: Jinyang Li, PhD (he/him/his) – Innovent Biologics (Suzhou) Co., Ltd.
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0910: Development of Four Distinct Human IgG4-Producing Mouse Models Recapitulating IgG4-Related Disease
Location: Hall F1
Abstract Poster Presenter: Min-Gang Kim, PhD – Seoul National University College of Medicine
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0930: Potent and Selective Oral IRF5 Degrader, KT 579, Blocks Pro-Inflammatory Cytokines and Reduces Joint Swelling in a Mouse Model of Rheumatoid Arthritis
Location: Hall F1
Abstract Poster Presenter: Ryan Camire, PhD – Kymera Therapeutics
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0907: Cross-Species Cellular Mapping and Humanization of Fcγ Receptors to Advance Antibody Modeling
Location: Hall F1
Abstract Poster Presenter: Karel Van Damme, MD, PhD – Ghent University Hospital
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0928: Radiolabelled anti-citrullinated histone antibody CIT-013 as a tool to visualize NET rich inflamed joints in a collagen induced arthritic mouse model
Location: Hall F1
Abstract Poster Presenter: Renato Chirivi, PhD, MSc – Citryll BV
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0904: SLAMF7 Drives Plasma Cell Differentiation in Rheumatoid Arthritis Synovium.
Location: Hall F1
Abstract Poster Presenter: Jabea Cyril Ekabe, MD, MS (he/him/his) – University of Rochester
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0918: Retention of variant forms of TNFR1 in the Golgi induces stress responses and monocyte activation in systemic Juvenile Idiopathic Arthritis (sJIA)
Location: Hall F1
Abstract Poster Presenter: Anthony Cruz, BS – National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0915: A Fusion of TACI Variant and Anti-ifnar Antibody with Greater Therapeutic Effect on Related Autoimmune Disease Models
Location: Hall F1
Abstract Poster Presenter: Yuhao Qin, n/a (he/him/his) – Jiangsu Hengrui Pharmaceuticals Co., Ltd
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0932: Compartment-specific NK-cell phenotypes reveal distinct maturation and activation states in inflammatory arthritis
Location: Hall F1
Abstract Poster Presenter: Wolfgang Merkt, MD – University Hospital Düsseldorf
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0925: Pathogenic role of SPP1+ macrophages in Rheumatoid Arthritis
Location: Hall F1
Abstract Poster Presenter: Megan M. Hanlon, PhD, BSc (she/her/hers) – Brigham and Women's Hospital, HMS
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0900: WITHDRAWN
Location: Hall F1
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0917: Synovial Tissue Neutrophils are Associated with Disease Activity and Early Remission in Rheumatoid Arthritis
Location: Hall F1
Abstract Poster Presenter: Annabelle Small, PhD, BSc – Flinders University
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0919: Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns
Location: Hall F1
Abstract Poster Presenter: Diego Kyburz, MD (he/him/his) – University Hospital Basel
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0912: CD11c⁺CD21⁻ Autoimmune-Associated B Cells Derived from Double-Negative IgD⁻CD27⁻ Subsets Exhibit Enhanced IFNLR1 Expression in Systemic Lupus Erythematosus
Location: Hall F1
Abstract Poster Presenter: ROUKAYA YAAKOUBI, PhD (she/her/hers) – University of Rochester
Monday, Oct 27th
10:30 AM - 12:30 PM Central Time
0921: Fibrinogen Co-Modified with Malondialdehyde-Acetaldehyde and Citrulline Promotes Pro-Inflammatory Macrophage Differentiation Through p38 and NF-κB Signaling
Location: Hall F1
Abstract Poster Presenter: Hannah Johnson, BS – University of Nebraska Medical Center
Monday, Oct 27th
1:00 PM - 2:30 PM Central Time
27M38: Abstracts: Cytokines & Cell Trafficking
Location: W192A-C
Abstract Moderator: Roxana Coras, MD, PhD – Cedars Sinai Medical Center
Abstract Moderator: Edward Schwarz, PhD – University of Rochester, Rochester, NY, USA
CE: 0.00
Monday, Oct 27th
1:00 PM - 1:15 PM Central Time
1650: Malondialdehyde-Acetaldehyde and Citrulline Modified Proteins are Overexpressed in Cardiac Tissues in Rheumatoid Arthritis-Associated Heart Failure and Mediate Endothelial Cell Dysfunction
Location: W192A-C
Presenting Author: Hannah Johnson, BS – University of Nebraska Medical Center
Monday, Oct 27th
1:15 PM - 1:30 PM Central Time
1651: Compound Heterozygosity for the Ile692del and Val726Ala Pathogenic MEFV Variants and Elevated IL-18 (CHIVE-18 syndrome) Is Distinct from Familial Mediterranean Fever (FMF) and Includes a Pronounced Response to Interferon Stimulation in Myeloid Cell Populations
Location: W192A-C
Presenting Author: Mary Maclean, PhD (she/her/hers) – NIAMS, NIH
Monday, Oct 27th
1:30 PM - 1:45 PM Central Time
1652: The Hidden Impact of Hyperuricemia on Immune Cell Dysfunction
Location: W192A-C
Presenting Author: Qian Wang, MD & PhD (she/her/hers) – iLab Research Institute
Monday, Oct 27th
1:45 PM - 2:00 PM Central Time
1653: Gut-joint lymphocyte trafficking functions to regulate systemic immunity
Location: W192A-C
Presenting Author: Sarah Danielson, BA – University of Colorado Anschutz Medical Campus
Monday, Oct 27th
2:00 PM - 2:15 PM Central Time
1654: A Dual Inhibitor of TAK1 and MAP4K2, NG25, Suppresses Cytokine-driven Inflammation in Juvenile Idiopathic Arthritis Synovial Fibroblasts
Location: W192A-C
Presenting Author: Meena Afroze Shanta, MS – College of Pharmacy and Pharmaceutical Science, Washington State University
Monday, Oct 27th
2:15 PM - 2:30 PM Central Time
1655: Aberrant Noncoding RNAs Are Enriched in Extracellular Vesicles and Implicated in Interferon Activation
Location: W192A-C
Presenting Author: Sandra Williams, MD, PhD – National Institutes of Health
Monday, Oct 27th
2:30 PM - 3:30 PM Central Time
27M54: Immunology Boot Camp 1: Basic Principles
Location: W184B-C
Moderator: Janet Bahr, NP – Family Neighborhood Clinic
Moderator: Neil Moody, Jr, BS, PA-C – Multicare Tacoma General Rheumatology Associates
Session Coordinator: Janet Bahr, NP – Family Neighborhood Clinic
CE: 1.00
Monday, Oct 27th
2:30 PM - 3:00 PM Central Time
Basics of Immunobiology
Location: W184B-C
Speaker: Troy Torgerson, MD;PhD – Allen Institute for Immunology
Monday, Oct 27th
3:00 PM - 4:30 PM Central Time
27M65: Abstracts: B Cell Biology & Targets in Autoimmune & Inflammatory Disease
Location: W183A-C
Abstract Moderator: Ken Yasaka, MD, PhD – University of Rochester
Abstract Moderator: Bharati Matta, PhD, MBA – The Feinstein Institutes for Medical Research
CE: 0.00
Monday, Oct 27th
3:00 PM - 3:15 PM Central Time
1692: Rheumatoid factor is associated with increased gut permeability and migration of B cells to the joint via CXCR3 in rheumatoid arthritis
Location: W183A-C
Presenting Author: Ken Yasaka, MD, PhD – University of Rochester
Monday, Oct 27th
3:15 PM - 3:30 PM Central Time
1693: Characterizing ANCA-specific B Cells in ANCA-associated Vasculitis
Location: W183A-C
Presenting Author: Laura van Dam, MD, PhD (she/her/hers) – Stanford University
Monday, Oct 27th
3:30 PM - 3:45 PM Central Time
1694: Obesity Exacerbates Autoimmunity by Dysregulating B Cell Behavior
Location: W183A-C
Presenting Author: Munir Akkaya, PhD (he/him/his) – The Ohio State University
Monday, Oct 27th
3:45 PM - 4:00 PM Central Time
1695: The B Cell Compartment Exhibits a Pro-Inflammatory Skewing During Progression to Rheumatoid Arthritis
Location: W183A-C
Presenting Author: Marla Glass, PhD – Allen Institute for Immunology
Monday, Oct 27th
4:00 PM - 4:15 PM Central Time
1696: A Multi-omics Resource of B Cell Activation Reveals Genetic Mechanisms for Autoimmune Diseases
Location: W183A-C
Presenting Author: Maria Gutierrez-Arcelus, PhD – Boston Children's Hospital
Monday, Oct 27th
4:15 PM - 4:30 PM Central Time
1697: Dynamic Effects of T cell Engager Therapy on B and T cells in Autoimmune Disease.
Location: W183A-C
Presenting Author: Laura Bucci, MD – Universitätsklinikum Erlangen - Med. 3
Monday, Oct 27th
4:15 PM - 5:15 PM Central Time
27M75: Tiny Tenants, Big Influence: Microbial Regulation of Host Immunity
Location: W475A-B
Moderator: Kelly Hudspeth, PhD – N/A
Moderator: Sadiq Umar, PhD – University of Illinois at Chicago
Session Coordinator: Sadiq Umar, PhD – University of Illinois at Chicago
CE: 1.00
Monday, Oct 27th
4:15 PM - 4:45 PM Central Time
Regulation of Bone Mass by the Gut Microbiome: Healthy, Inflammatory, and Aging Microbiomes
Location: W475A-B
Speaker: Abdul Malik, PhD – Orthopaedic Surgery Research
Monday, Oct 27th
4:45 PM - 5:15 PM Central Time
Gut Commensal Protozoa: Key Modulators of Immunity and Disease Outcomes
Location: W475A-B
Speaker: Arthur Mortha, PhD – University of Toronto
Tuesday, Oct 28th
10:00 AM - 11:30 AM Central Time
28T23: Bypassing the 'Toll' Booth: NIAID-Supported Insights into Alternative Nucleic Acid Sensing in Autoimmunity
Location: W181A-C
Moderator: Jeffrey Rice, PhD – National Institute of Allergy and Infectious Diseases (NIH/NIAID)
Moderator: Christian Lood, PhD – University of Washington
Session Coordinator: Carla Cuda, PhD – Northwestern University
CE: 1.50
Tuesday, Oct 28th
10:00 AM - 10:30 AM Central Time
RNA Editing and Sensing as a Common Mechanism Underlying Genetic Risk of Autoinflammatory Diseases
Location: W181A-C
Speaker: Jin Billy Li, PhD – Stanford University
Tuesday, Oct 28th
10:30 AM - 11:00 AM Central Time
RNA Platforms Regulate MAVS-Dependent Interferon Activation
Location: W181A-C
Speaker: Ram Savan, PhD – University of Washington
Tuesday, Oct 28th
11:00 AM - 11:30 AM Central Time
Intracellular Nucleic Acid Detection in Autoimmunity
Location: W181A-C
Speaker: Ann Marshak-Rothstein, PhD – UMass Chan Medical School
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
Cytokines & Cell Trafficking Poster
Location: Hall F1
CE: 0.00
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1779: Citrullinated and Malondialdehyde-Acetaldehyde Modified Fibrinogen Activates Macrophages and Induces Inflammatory Responses in Coronary Endothelium
Location: Hall F1
Abstract Poster Presenter: Wenxian Zhou, BS – University of Nebraska Medical Center
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1771: Interferon- α, Anti-Interferon-Alpha Antibodies and Disease Activity in Systemic Lupus Erythematosus
Location: Hall F1
Abstract Poster Presenter: Gollakota Nandita, MBBS/MD – NIMS, Hyderabad
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1778: Towards an Earlier and Accurate Diagnosis of Connective Tissue Disease-related Interstitial Lung Disease: TGFB Isoform Genes as Upcoming Biomarkers
Location: Hall F1
Abstract Poster Presenter: Verónica Pulito Cueto, PhD – IDIVAL
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1772: Correlation between Soluble Checkpoint Molecules and Disease Activity in Autoimmune Diseases
Location: Hall F1
Abstract Poster Presenter: Kosaku Murakami, MD, PhD (he/him/his) – Kyoto University
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1774: Citrullinated and Malondialdehyde-Acetaldehyde Co-Modified Fibrinogen Activates Macrophages and Induces Pro-Fibrotic shift in Coronary Endothelium Phenotype
Location: Hall F1
Abstract Poster Presenter: Nozima Aripova, PhD – University of Nebraska Medical Center
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1773: Redefining disease activity assessment in IgG4-Related Disease: The role of classical and novel biomarkers
Location: Hall F1
Abstract Poster Presenter: Marta López, MD – Complex Hospitalari Universitari Moisès Broggi
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1770: Brepocitinib Inhibits Key Pathogenic Cytokine Signaling in Dermatomyositis Patients
Location: Hall F1
Abstract Poster Presenter: Christina Charles-Schoeman, MD;MS – UCLA Medical Center
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1777: Granzyme B as a regulator of interferon alpha production in cutaneous lupus erythematosus
Location: Hall F1
Abstract Poster Presenter: Touraj Khosravi, MD, FRCPC, FAAD – University of British Columbia
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1776: Preclinical Development of a Novel TL1A-Targeting Antibody with Extended Half-life and Low Immunogenicity Risk for the Treatment of Inflammatory Diseases
Location: Hall F1
Abstract Poster Presenter: Quan Yu, PhD – Ailux
Tuesday, Oct 28th
10:30 AM - 12:30 PM Central Time
1775: Study Of Type -1 Interferon Gene Signature Markers In Muscle Biopsy Samples Of Patients With IIM
Location: Hall F1
Abstract Poster Presenter: pradeep sosigowda, MBBS/MD/DM – NIMS
Tuesday, Oct 28th
1:00 PM - 2:30 PM Central Time
28T34: Abstracts: Innate Immunity (2579–2584)
Location: W183A-C
Abstract Moderator: Insoo Kang, MD – Yale School of Medicine
Abstract Moderator: Matthew Stoll, MD, PhD – University of Alabama at Birmingham
CE: 0.00
Tuesday, Oct 28th
1:00 PM - 1:15 PM Central Time
2579: Mutant COPA Permits Aberrant NETosis and Exacerbates Autoimmune Lung Disease
Location: W183A-C
Presenting Author: Richard Moore, BSc (he/him/his) – Cedars-Sinai
Tuesday, Oct 28th
1:15 PM - 1:30 PM Central Time
2580: Estrogen Modulates Neutrophil Biology: Implications for Autoimmunity
Location: W183A-C
Presenting Author: William Ambler, MD – NIH/NIAMS
Tuesday, Oct 28th
1:30 PM - 1:45 PM Central Time
2581: From Skin to Kidney: Neutrophil-Mediated Crosstalk Links Cutaneous Injury to Renal Inflammation and Vascular Remodeling in Lupus
Location: W183A-C
Presenting Author: Angelique Cortez, BS – Dartmouth College
Tuesday, Oct 28th
1:45 PM - 2:00 PM Central Time
2582: Inflammatory Cell Death and Impaired Efferocytosis Drive Monocyte and Macrophage Dysfunction in VEXAS Syndrome.
Location: W183A-C
Presenting Author: Paul Breillat, MD – INSERM
Tuesday, Oct 28th
2:00 PM - 2:15 PM Central Time
2583: WITHDRAWN
Location: W183A-C
Tuesday, Oct 28th
2:15 PM - 2:30 PM Central Time
2584: Spatially Resolved Transcriptomics Reveal Macrophage Heterogeneity in Giant Cell Arteritis
Location: W183A-C
Presenting Author: Lea Dionet, PhD – INSERM
Tuesday, Oct 28th
2:30 PM - 3:30 PM Central Time
28T50: Immunology Boot Camp II: Applying Principles to Practice
Location: W184B-C
Moderator: Janet Bahr, NP – Family Neighborhood Clinic
Moderator: Neil Moody, Jr, BS, PA-C – Multicare Tacoma General Rheumatology Associates
Session Coordinator: Janet Bahr, NP – Family Neighborhood Clinic
CE: 1.00
Tuesday, Oct 28th
2:30 PM - 3:30 PM Central Time
28T51: Bringing Sexy Back: Sex Hormone Modulation of Immune Responses in Autoimmunity
Location: W475A-B
Moderator: Melissa Cunningham, MD, PhD – Medical University of South Carolina
Moderator: Caroline Jefferies, PhD – Cedars-Sinai Medical Center
Session Coordinator: Caroline Jefferies, PhD – Cedars-Sinai Medical Center
CE: 1.00
Tuesday, Oct 28th
2:30 PM - 3:00 PM Central Time
Immunobiology of Therapeutics
Location: W184B-C
Speaker: Troy Torgerson, MD;PhD – Allen Institute for Immunology
Tuesday, Oct 28th
2:30 PM - 3:00 PM Central Time
Obesity Influences Sex-Specific Interferon Signaling to Alter MS
Location: W475A-B
Speaker: Shannon Dunn, PhD – U Toronto and Sunnybrook Research Institute
Tuesday, Oct 28th
3:00 PM - 3:30 PM Central Time
Immune System Adaptation During Gender-Affirming Testosterone Treatment
Location: W475A-B
Speaker: Petter Brodin, MD, PhD – Karolinska Institut
Tuesday, Oct 28th
4:00 PM - 5:00 PM Central Time
28T65: Stressed Out!: The Role of Cellular Stress in Autoimmune Disease
Location: W475A-B
Moderator: William Ambler, MD – NIH/NIAMS
Moderator: Andras Perl, MD, PhD – SUNY
Session Coordinator: Theresa Lu, MD;PhD – Hospital for Special Surgery
CE: 1.00
Tuesday, Oct 28th
4:00 PM - 4:30 PM Central Time
Chronic Activation of Plasmacytoid Dendritic Cells in Autoimmunity Is Linked to Dysregulated ER Stress and Metabolic Responses
Location: W475A-B
Speaker: Franck Barrat, PhD – Hospital for Special Surgery
Tuesday, Oct 28th
4:30 PM - 5:00 PM Central Time
The Role of Oxidative Stress in Autoimmune Skin Disease
Location: W475A-B
Speaker: Mehdi Rashighi, MD – UMass Chan Medical School