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Program: Scientific Session

Aging
General Topic: Basic Science

26S35: We Are Not Getting Any Younger: Regulating Immune Responses During Inflammation and Aging

Sunday, October 26, 2025
1:00 PM - 2:30 PM Central Time
Location: W181A-C
CE: 1.50

CME In Person On Demand

    Moderator(s)

  • CJ

    Caroline Jefferies, PhD

    Cedars-Sinai Medical Center
    Beverly Hills, California, United States

    Disclosure(s): Amgen: Stock options or bond holdings in a for-profit corporation or self-directed pension plan (Ongoing); Eli Lilly: Stock options or bond holdings in a for-profit corporation or self-directed pension plan (Ongoing)

  • BB

    Betsy Barnes, PhD

    Northwell Health
    Manhasset, New York, United States

    Disclosure information not submitted.

    • Session Coordinator(s)

  • Sadiq Umar, PhD

    University of Illinois at Chicago
    Chicago, Illinois, United States

    Disclosure(s): No financial relationships with ineligible companies to disclose

This session will define and discuss inflammaging - the chronic, low-grade inflammation that accompanies aging, and its role in the development and progression of rheumatic diseases. Mechanisms driving age-related immune dysfunction, their role in progression of rheumatic diseases, as well as a novel mechanisms to regulate macrophage function in rheumatic disease will be discussed.

Learning Objectives:

  • Define inflammaging as a driver of autoimmune disease
  • Interpret how T cells are remodeled in inflammaging
  • Categorize how myelopoiesis is affected in inflammaging in autoimmunity

Presentations:

  • 1:00 PM - 1:30 PM Central Time
    Age-related Naive T-cell Remodeling

    Speaker: Maxim Artyomov, PhD – Washington University in St Louis

  • 1:30 PM - 2:00 PM Central Time
    Aging Blood from the Inside Out: How Megakaryocytes Shape Aging of the Immune System

    Speaker: Sandra Pinho, PhD – College of Medicine, University of Illinois at Chicago

  • 2:00 PM - 2:30 PM Central Time
    Transcription Control and Therapeutic Targeting of Macrophage Responses During Inflammation and Inflammatory Arthritis

    Speaker: Inez Rogatsky, PhD – Hospital for Special Surgery