Old Dog, New Tricks: Regulation of Autoinflammation and Autoimmunity Informed by Inborn Errors of Immunity

Monday, October 27, 2025

1:00 PM - 2:00 PM Central Time

CE: 1

Moderator(s)

Polly Ferguson, MD

University of Iowa Carver College of Medicine
Iowa City, IA, United States

Disclosure information not submitted.
Tiphanie Vogel, MD;PhD

Baylor College of Medicine
Houston, TX, United States

Disclosure(s): AstraZeneca: Grant/Research Support (Ongoing); Moderna: Consultant (Terminated); Pfizer: Consultant (Ongoing); SOBI: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing); Takeda: Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing)

Session Coordinator(s)

Polly Ferguson, MD

University of Iowa Carver College of Medicine
Iowa City, IA, United States

Disclosure information not submitted.

Why do genetic immune diseases manifest with different phenotypes in different people? In this session, renowned immunologist Dr. Bogunovic discusses an exciting new detective story of how a monogenic disorder can be expressed differently in different individuals.

Learning Objectives:

Recognize that inborn errors of immunity are genetic disorders that can underlie susceptibility to infection, autoimmunity, autoinflammation, allergy and/or malignancy or a combination of these problems.
Understand that for many monogenic inborn errors of immunity there may be significant genotype-phenotype variability.
Recognize that phenotypic variability in monogenic inborn errors of immunity may be due to random commitment to the expression from one allele instead of two (similar to what occurs in X inactivation) and that this process is called autosomal random monoallelic expression (aRMAE).

Presentations:

1:00 PM - 2:00 PM Central Time

Incomplete Penetrance in Autoinflammatory Diseases – Role for Monoallelic Expression
Speaker: Dusan Bogunovic, PhD – Columbia University Medical Center