Old Dog, New Tricks: Regulation of Transciption Informed by Inborn Errors of Immunity

Moderator(s)

• 

  Polly Ferguson, MD

  University of Iowa Carver College of Medicine
  Iowa City, IA, United States

  Disclosure information not submitted.
• 

  Tiphanie Vogel, MD, PhD

  Baylor College of Medicine
  Houston, Texas, United States

  Disclosure(s): AstraZeneca: Grant/Research Support (Ongoing); Moderna: Consultant (Terminated); Pfizer: Consultant (Ongoing); SOBI: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing); Takeda: Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing)

Session Coordinator(s)

• 

  Polly Ferguson, MD

  University of Iowa Carver College of Medicine
  Iowa City, IA, United States

  Disclosure information not submitted.

Immune dysregulation resulting from inborn errors of immunity can present with phenotypes that cross diagnostic categories. An individual may have features of autoinflammatory, autoimmune, allergic, infectious, and/or oncologic processes complicating the care of affected individuals. Pinpointing the genetic cause for the immune dysregulation not only allows a specific diagnosis, but facilitates dissection of the mechanisms that lead to alterations in seemingly distinct parts of the immune system. This basic mechanistic data informs about basic immunologic processes and can help guide therapeutic approaches.

Presentations:

• 1:00 PM – 2:00 PM Central Time

  Insights into Autoinflammation and Autoimmunity: Lessons Learned from Inborn Errors of Immunity
  

  Speaker: Dusan Bogunovic, PhD – Columbia University Medical Center