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Final Program


Schedule at a Glance
Legend
Program: Scientific Session
General Topic: Basic Science

The Good, the Bad, and the Ugly: Understanding Mechanisms of Adverse Events After Immune Checkpoint Therapy

Tuesday, October 28, 2025
8:30 AM - 9:30 AM Central Time
CE: 1

    Moderator(s)

  • Sophia Weinmann, MD, FACR

    Duke University
    Durham, North Carolina, United States

    Disclosure(s): No financial relationships with ineligible companies to disclose

    • Session Coordinator(s)

  • Teresa Tarrant, MD

    Duke University
    Durham, North Carolina, United States

    Disclosure(s): Amgen: Grant/Research Support (Ongoing); Chiesi: Consultant (Ongoing), Grant/Research Support (Ongoing); Department of Justice: Consultant (Ongoing); X4 Pharmaceuticals: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Grant/Research Support (Ongoing)

Immune checkpoint inhibitors are monoclonal antibodies targeting anti-cytotoxic T-lymphocyte antigen-4 (CTLA4), anti-programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1), and anti-lymphocyte activating-3 (LAG3) to enhance anti-tumor immunity. Unfortunately, checkpoint inhibitors may cause off-target immune-related adverse events (irAE) affecting any organ system. This session will discuss recent scientific advances that may play important pathogenic roles in irAE inflammatory responses leading to arthritis and myositis.

Learning Objectives:

  • Describe how immune checkpoint inhibitors influence the immune response
  • Demonstrate the effects of checkpoint inhibitors on T-cell responses
  • Define hallmarks of inflammatory arthritis and myositis as a consequence of immune-related adverse events

Presentations:

  • 8:30 AM - 8:50 AM Central Time
    Pathogenesis of Immune checkpoint inhibitors-induced myocarditis

    Speaker: Daniela Cihakova, PhD – Johns Hopkins University

  • 8:50 AM - 9:10 AM Central Time
    Molecular and Immune Hallmarks of Immune-Related Adverse Event Inflammatory Arthritis Induced by Checkpoint Inhibitors

    Speaker: Roza Nurieva, PhD – University of Texas MD Anderson

  • 9:10 AM - 9:30 AM Central Time
    Mouse Model of Immune-Related Adverse Events

    Speaker: Abby Overacre, PhD – University of Pittsburgh