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Poster Session

Crystal Arthropathies

Poster Session C

Session: (1990–2014) Metabolic & Crystal Arthropathies – Basic & Clinical Science Poster II

2005: Elevated Serum Uric Acid as an Independent Risk Factor for Multiple Stent Placement in Non-Hypertensive, Non-Diabetic Patients with Coronary Artery Disease: A Retrospective Cohort Analysis

Tuesday, October 28, 2025
10:30 AM - 12:30 PM Central Time
Location: Hall F1

    Abstract Poster Presenter(s)

  • LA

    Lemei An, MD

    Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital
    zhengzhou, Henan, China

    Disclosure(s): No financial relationships with ineligible companies to disclose


Background/Purpose: While the relationship between serum uric acid (SUA) and coronary artery disease (CAD) remains controversial, emerging evidence suggests a particularly significant association in patients lacking traditional cardiovascular risk factors. The specific role of hyperuricemia in determining CAD severity in non-hypertensive, non-diabetic populations warrants further investigation.

Methods: In this retrospective cohort study, we analyzed 716 consecutive CAD patients undergoing percutaneous coronary intervention (PCI), with a focus on 279 individuals without hypertension or diabetes. We employed multivariable logistic regression and stratified analyses to assess the independent association between SUA levels and multiple stent implantation (≥2 stents), a robust indicator of CAD complexity and prognosis. Hyperuricemia was defined using gender-specific thresholds ( >420 μmol/L for males and postmenopausal females; >360 μmol/L for premenopausal females).

Results: In the overall cohort, multivessel disease (OR=2.27, 95% CI:1.94–3.96, p< 0.001) and diabetes (OR=1.47, 95% CI:1.05–2.07, p=0.027) independently predicted multiple stent placement. Notably, in the non-hypertensive, non-diabetic subgroup, hyperuricemia emerged as a strong independent predictor (OR=4.62, 95% CI:1.93–11.07, p=0.001), exceeding the predictive value of multivessel disease (OR=3.16, 95% CI:1.78–5.55, p< 0.001). No significant association was observed between SUA levels and stent number in the broader cohort.

Conclusion: Elevated serum uric acid independently predicts complex coronary lesions requiring multiple stent placements in non-hypertensive, non-diabetic CAD patients. These findings suggest that uric acid assessment may enhance risk stratification in this specific patient population, warranting further investigation into its clinical implications.