University of Pennsylvania
Philadelphia, Pennsylvania, United States
Since January 2025, I have been an Assistant Professor in the Department of Pathology at the Perelman School of Medicine, University of Pennsylvania. During my postdoctoral tenure, I co-developed TScan-I, a high-throughput, genome-scale screening platform engineered to interrogate the antigenic landscape recognized by CD8⁺ T cells (Cell 2019). Building upon this foundation, I developed TScan-II, a complementary platform designed to unmask CD4⁺ T cell epitopes using genome-scale human and virome libraries (Cell 2023). More recently, my team and I developed TCR-MAP—a hybrid computational-experimental platform for high-resolution mapping of mouse T cell specificities (Nature Biotechnology 2024). Collectively, these platforms harness endogenous antigen processing, intricate T cell signal transduction, and systematic receptor–antigen pairing to delineate physiologically relevant T cell responses with unprecedented granularity.
My laboratory exploits these methodologies to dissect the antigenic determinants orchestrating T cell-mediated immunity across oncologic, infectious, and autoimmune paradigms. By characterizing tumor-specific and pathogen-derived T-cell antigens, we aim to elucidate novel immunotherapeutic targets and refine TCR-based therapeutic strategies, including next-generation cancer vaccines. Concurrently, our research extends to deciphering the immunological circuitry underpinning aberrant antigen recognition that drives autoimmune pathogenesis.
Sunday, October 26, 2025
9:00 AM – 9:30 AM Central Time
Disclosure(s): No financial relationships with ineligible companies to disclose
