Washington University School of Medicine
St. Louis, MO, United States
Dr. Artyomov is a Systems Immunologist, focused on investigating complex immune phenotypes by integrating traditional experimental techniques with the high-throughput data generation and analysis. I am currently an Alumni Endowed Professor at the Department of the Pathology&Immunology working at the Washington University in St.Louis since 2012. In the context of immunometabolism, we discovered and validated novel metabolic mechanisms controlling macrophage polarization as well as provided a comprehensive description of the global metabo-transcriptional rewiring (Immunity, 2015, e.g. aspartate-argininosuccinate shunt in proinflammatory macrophages, roles of glutamine and UDP-GLcNAc in alternative activation). We then followed up to discover the immunoregulatory properties of itaconate and describe it’s inhibition of Sdh, natural metabolite produced by activating macrophages (Cell Metabolism, 2016; Nature, 2018; J Exp Med, 2018; Nature Review Immunology, 2019; Nature Metabolism, 2020; Cell Reports, 2021). In our latest work we report novel itaconate phenotypes and describe molecular mechanism of itaconate’s regulatory action (Nature Metabolism, 2025). We also develop computational tools for the analysis of metabolic networks (Nuc Acid Res, 2016; Cell Reports, 2023).
Age-Related Naive T-Cell Remodeling
Sunday, October 26, 2025
1:00 PM – 1:30 PM Central Time
Disclosure(s): No financial relationships with ineligible companies to disclose
