(1830–1854) Systemic Lupus Erythematosus – Etiology and Pathogenesis Poster

Tuesday, October 28, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

Breathomics in Systemic Lupus Erythematosus: uncovering non-invasive markers of disease activity
Abstract Poster Presenter: Lorenzo Beretta, MD – Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MIlano
10:30 AM - 12:30 PM Central Time

Cellular Landscape of Cutaneous Lupus Erythematosus Revealed by Single-Cell RNA Sequencing and Spatial Transcriptomics in the Lupus Accelerating Medicine Partnership Cohort
Abstract Poster Presenter: Victoria Werth, MD – University of Pennsylvania
10:30 AM - 12:30 PM Central Time

Differential Expression Of Activation Markers On dsDNA-reactive B-cells Between Healthy Subjects And SLE Patients Reveals Unconventional Extrafollicular Activation In SLE
Abstract Poster Presenter: Jolien Suurmond, PhD – Leiden University Medical Center
10:30 AM - 12:30 PM Central Time

Differential metabolomic signatures along lupus nephritis spectrum
Abstract Poster Presenter: Mariana Jiménez Tirado, MD (she/her/hers) – Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
10:30 AM - 12:30 PM Central Time

Disease-Associated Macrophages Express an Injury-Associated Gene Program and Localize to Distinct Compartments in Proliferative and Mixed Histologic Classes of Lupus Nephritis
Abstract Poster Presenter: Paul Hoover, MD, PhD – Brigham and Women's Hospital
10:30 AM - 12:30 PM Central Time

Distinct Proteomic Signature Predicts Post-MMF Withdrawal Flares in Systemic Lupus Erythematosus Patients
Abstract Poster Presenter: Christian Wright, BS – University of Oklahoma Health Sciences Center
10:30 AM - 12:30 PM Central Time

DM618: A Novel Anti-IL12p35 Antibody Specifically Inhibiting IL-12 with Therapeutic Potential in a Set of Autoimmune Diseases
Abstract Poster Presenter: DONG ZHANG, PhD (he/him/his) – D2M Biotherapeutics, Inc.
10:30 AM - 12:30 PM Central Time

DS-7011a, An Anti-TLR7 Antagonistic Monoclonal Antibody, Suppresses Human Immune Cells and Multiple Cytokines/Chemokines Related to the Pathogenesis of SLE
Abstract Poster Presenter: Shigeko Uryu, MSc – Daiichisankyo Co.,Ltd.
10:30 AM - 12:30 PM Central Time

Emerging Role of B Cell Subtype-Specific Intracytoplasmic Toll-Like Receptor Expression and Serum Eotaxin as Biomarkers in Lupus Nephritis
Abstract Poster Presenter: Jennifer Balderas Miranda, MD, PhD (she/her/hers) – Universidad Nacional Autónoma de México
10:30 AM - 12:30 PM Central Time

Endotype Discovery in Systemic Lupus Erythematosus Using Multi-Omic Approaches: Toward Precision Insights into Cardiovascular and Renal Damage
Abstract Poster Presenter: Tomás Cerdó, PhD – Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain
10:30 AM - 12:30 PM Central Time

Enhanced Mitochondrial Activity in B cells from Females Is Required to Drive Increased T-bet Induction by TLR7 in Lupus
Abstract Poster Presenter: John D. Mountz, MD, PhD – University Alabama Birmingham
10:30 AM - 12:30 PM Central Time

First American SLE patients demonstrate enhanced lipid metabolism and B cell activation by high-content proteomic analyses
Abstract Poster Presenter: Tayte Stephens, BS – University of Oklahoma Health Science Center
10:30 AM - 12:30 PM Central Time

Immune Cell Profiles and Transcriptomic Signatures of Atherosclerosis in Systemic Lupus Erythemathosus
Abstract Poster Presenter: Rodolfo Martinez-Canales, MD (he/him/his) – Facultad de Medicina y Hospital Universitario UANL
10:30 AM - 12:30 PM Central Time

Integrated spatial and single-cell profiling of treatment-naïve lupus nephritis biopsies
Abstract Poster Presenter: Roopa Madhu, PhD – Brigham and Women's Hospital
10:30 AM - 12:30 PM Central Time

Integrative Bioinformatics Analysis Reveals Key Genes and Immune Profiles Associated with Preeclampsia in Lupus Pregnancy
Abstract Poster Presenter: Eva Galindo Calvillo, MD (she/her/hers) – Hospital Universitario Dr. Jose Eleuterio Gonzalez
10:30 AM - 12:30 PM Central Time

Resting-State Functional Magnetic Resonance Imaging Analysis Revealed Altered Functional Connectivity Associated with Fatigue in Systemic Lupus Erythematosus
Abstract Poster Presenter: Yujie Song, MB – Hokkaido University
10:30 AM - 12:30 PM Central Time

SAP Expression in SLE T Cells is Associated with Differentiation Towards Pro-Inflammatory Effector Subsets.
Abstract Poster Presenter: Yevgeniya Gartshteyn, MD, MS – Columbia University Medical Center
10:30 AM - 12:30 PM Central Time

Serum Zonulin As A Biomarker Of Renal Involvement In Systemic Lupus Erythematosus: Shedding Light On The Gut-Kidney Axis
Abstract Poster Presenter: Giulio Forte, n/a – Università della Campania Luigi Vanvitelli
10:30 AM - 12:30 PM Central Time

Single-Cell and Spatial Profiling Reveal Proinflammatory and Profibrotic Fibroblast-Macrophage Niches in Lupus Nephritis
Abstract Poster Presenter: Chirag Raparia, PhD, MS, BS (he/him/his) – Donald and Barbara Zucker School of Medicine At Hofstra/Northwell
10:30 AM - 12:30 PM Central Time

Social Vulnerability Index, Type 2 Lupus Symptoms, and Select Dysregulated Immune Features Identify Stage 2 (Pre-classification) SLE in the Lupus Autoimmunity in Relatives (LAUREL) Follow-up Cohort
Abstract Poster Presenter: Melissa Munroe, MD, PhD (she/her/hers) – Oklahoma Medical Research Foundation; Progentec Diagnostics, Inc.
10:30 AM - 12:30 PM Central Time

Spatial transcriptomics reveals a complex microanatomic patterning of complement mediated inflammation and fibrosis in Class III pediatric lupus nephritis associated with local histologic injury
Abstract Poster Presenter: Sarah McCuaig, MD, PhD (she/her/hers) – Children's Hospital of Philadelphia
10:30 AM - 12:30 PM Central Time

Time-course RNA sequencing analysis of longitudinal peripheral blood samples to elucidate the factors determining treatment resistance in systemic lupus erythematosus
Abstract Poster Presenter: Shuji Sumitomo, MD, PhD (he/him/his) – Kobe City Medical Center General Hospital
10:30 AM - 12:30 PM Central Time

Time-to-Event Analysis of Statin Use and Thrombotic Risk in Patients with Systemic Lupus Erythematosus: A Single-Center Retrospective Study
Abstract Poster Presenter: Christine Lenchur, DO – Icahn School of Medicine at Mount Sinai
10:30 AM - 12:30 PM Central Time

Tissue Neutrophils in The Pathogenesis of Lupus Nephritis
Abstract Poster Presenter: Norio Hanata, M.D., Ph.D. – Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
10:30 AM - 12:30 PM Central Time

Transcriptional Profiling of Whole Blood and Kidney Biopsy Samples from Lupus Nephritis and IgA Nephropathy Patients Suggests Different Disease Pathways
Abstract Poster Presenter: Loqmane seridi, PhD – J&J