(1809–1829) Pediatric Rheumatology – Basic Science Poster

Tuesday, October 28, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

Mass Spectrometry-Based N-Terminomics Uncovers Proteolytic Signatures and Pathways in Juvenile Idiopathic Arthritis Synovial Fluid
Abstract Poster Presenter: Andrew Zeft, MD, MPH – Cleveland Clinic
10:30 AM - 12:30 PM Central Time

The Circulating Immune Profile of Systemic JIA Patients with HLA-DRB1*15 alleles, Eosinophilia, and Lung Disease
Abstract Poster Presenter: Jennifer Cheng, BA – Boston Children's Hospital
10:30 AM - 12:30 PM Central Time

Spatial Transcriptomic Profiling Reveals Interferon Activation and CD8⁺ T Cell Dominance in Systemic Juvenile Idiopathic Arthritis-Macrophage Activation Syndrome Liver Inflammation
Abstract Poster Presenter: Esraa Eloseily, MD, MSc – UT Southwestern Children's Medical Center
10:30 AM - 12:30 PM Central Time

Cytokine profiling in refractory systemic juvenile idiopathic arthritis reveals distinct signatures for macrophage activation syndrome and lung disease.
Abstract Poster Presenter: Grant Schulert, MD, PhD – Cincinnati Children's Hospital Medical Center
10:30 AM - 12:30 PM Central Time

Genome-Wide DNA Methylation Analysis in Familial Mediterranean Fever
Abstract Poster Presenter: Kader Cetin Gedik, MD – UPMC Children's Hospital of Pittsburgh/University of Pittsburgh
10:30 AM - 12:30 PM Central Time

Transcriptomics and Machine Learning Unraveling the Molecular Drivers of PFAPA Flares
Abstract Poster Presenter: Sivia Lapidus, MD – Hackensack University Medical Center
10:30 AM - 12:30 PM Central Time

Single Nuclei Multiome of JDM Muscle Biopsies Reveals Novel Upregulation of Inflammatory and Vascular Pathways
Abstract Poster Presenter: Shannon O'Connor, MD, PhD – Cincinnati Children's Hospital Medical Center
10:30 AM - 12:30 PM Central Time

Tissue-Resident Natural Killer Cells May Drive Monocyte Differentiation And Macrophage Accumulation In The Inflamed Joints Of Pediatric Juvenile Idiopathic Arthritis Patients
Abstract Poster Presenter: Roselyn Fierkens, BS – University of Colorado-Anschutz Medical Campus
10:30 AM - 12:30 PM Central Time

CD14+CXCL10+Monocytes Remodel the Peripheral Immune Network in sJIA via UBE2D1-Driven Inflammatory Programming
Abstract Poster Presenter: Xuemei Tang, MD, Professor, Chief Physician – Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders
10:30 AM - 12:30 PM Central Time

New-Onset Juvenile Spondyloarthritis is Characterized by Bone Metabolism Disturbances with Biomarker Potential
Abstract Poster Presenter: Brittney Newby, MD;PhD (she/her/hers) – Children's Hospital of Philadelphia
10:30 AM - 12:30 PM Central Time

Frequency of Tissue-Specific Activated CD8+ T Cells is Correlated To Disease Severity in Juvenile Idiopathic Arthritis
Abstract Poster Presenter: Abigail Thielbar, BS – Cincinnati Children's Hospital Medical Center
10:30 AM - 12:30 PM Central Time

Inflammasome and UPR activation in monocytes of HLA B27 positive children with Enthesitis related arthritis category of JIA
Abstract Poster Presenter: Shivika Guleria, MSc – SGPGIMS, Lucknow
10:30 AM - 12:30 PM Central Time

Multiomic Investigation of Juvenile Idiopathic Arthritis Synovium Reveals Immune Cell Heterogeneity
Abstract Poster Presenter: Yuriy Baglaenko, PhD – Cincinnati Children's Hospital
10:30 AM - 12:30 PM Central Time

Trapped in the NET: Impaired DNase function and targeted antibodies in the pathogenesis of pediatric lupus nephritis
Abstract Poster Presenter: Bharati Matta, PhD, MBA – The Feinstein Institutes for Medical Research
10:30 AM - 12:30 PM Central Time

Pharmacogenomic analysis of prediction of IL-1 Inhibitor treatment response in the CARRA First-line Options for Systemic Juvenile Idiopathic Arthritis Treatment (FROST) Study
Abstract Poster Presenter: Mariana Correia Marques, MD – National Institutes of Health
10:30 AM - 12:30 PM Central Time

Destabilized Treg Cells Predominant in Severe Forms of Juvenile Idiopathic Arthritis
Abstract Poster Presenter: Ki Pui Lam, PhD – Division of Immunology, Boston Childrens Hospital, Harvard Medical School
10:30 AM - 12:30 PM Central Time

Epigenetic Profiling of Childhood-onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity
Abstract Poster Presenter: Desire Casares Marfil, PhD – School of Medicine, University of Pittsburgh
10:30 AM - 12:30 PM Central Time

Sex-specific mechanisms associated with female childhood-onset systemic lupus erythematosus revealed by transcriptomic analysis of transgender adolescents undergoing gender-affirming sex hormone therapy.
Abstract Poster Presenter: Coziana Ciurtin, MD, PhD, FRCP – University College London
10:30 AM - 12:30 PM Central Time

Serum proteomic and single cell RNA sequencing analysis reveals macrophage activation syndrome physiology and widespread complement dysregulation are associated with severe dengue infection in a pediatric cohort
Abstract Poster Presenter: Sarah McCuaig, MD, PhD (she/her/hers) – Children's Hospital of Philadelphia
10:30 AM - 12:30 PM Central Time

Single-Cell RNA-Transcriptomics of JDM Skin Identifies JDM-Associated Immune Cell Populations and Dysregulated Interferon Signaling in Immune and Endothelial Cells
Abstract Poster Presenter: Chioma Madubata, MD, PhD – UCSF
10:30 AM - 12:30 PM Central Time

Transcriptiomics of tear RNA from children with active and inactive chronic anterior uveitis
Abstract Poster Presenter: Grant Schulert, MD, PhD – Cincinnati Children's Hospital Medical Center