(0978–1006) T Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster

Monday, October 27, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

A Deep-learning Based Approach Uncovers Novel Mediators of Micro-rna Restraint of type-2 Immunity
Abstract Poster Presenter: Shaan Sekhon, BA – CNU College of Medicine
10:30 AM - 12:30 PM Central Time

Ai-guided Generation and Preclinical Evaluation of an OX40L-IL31 Bispecific Antibody
Abstract Poster Presenter: Zhenping Zhu, n/a – Helixon Therapeutics
10:30 AM - 12:30 PM Central Time

An Fc-engineered Agonistic anti-pd-1 Antibody Selectively Depletes pd-1⁺ Cells and Attenuates T Cell Activation in vitro and in vivo in a Xenogeneic Graft-versus-host Disease (GvHD) Model
Abstract Poster Presenter: Laetitia POUZOL, PhD, PharmD (she/her/hers) – Anaveon
10:30 AM - 12:30 PM Central Time

ATF3 Inhibits Pulmonary Fibrosis via CD4+CD25−LAG3+ T Cells
Abstract Poster Presenter: Xiao Zhang, n/a – The Eighth Affiliated Hospital of Sun Yat-sen University
10:30 AM - 12:30 PM Central Time

Breaking Inflammatory Pathways: ELN28, a Novel Dual TNFα/JAK Inhibitor Drug Conjugate for Chronic Inflammation
Abstract Poster Presenter: Obinna Ubah, PhD – Elasmogen Limited
10:30 AM - 12:30 PM Central Time

CD49a Contributes to Binding and Survival of Synovial Resident Memory T cells
Abstract Poster Presenter: Yusuke Miyashita, MD, PhD (he/him/his) – Boston Children's Hospital
10:30 AM - 12:30 PM Central Time

Detecting Autoreactive CD4+ T Cells Relevant to Mixed Connective Tissue Disease
Abstract Poster Presenter: Grace Frechette, BS – Creighton University
10:30 AM - 12:30 PM Central Time

Distinct Effects of Inhibitory Receptor Agonism on RA Synovial CD4+ T Cell Functions
Abstract Poster Presenter: Kazuhiko Higashioka, MD, PhD – Brigham and Women's Hospital
10:30 AM - 12:30 PM Central Time

Expansion of Viral-Reactive CD8+ T cell Repertoire Stratified by Pathotype in New-onset ACPA+ Rheumatoid Arthritis
Abstract Poster Presenter: Carl Coyle, PhD – King's College London
10:30 AM - 12:30 PM Central Time

FoxP3^Lo CD4⁺ T cells are functionally suppressive and expanded in the immune-mediated fibrotic diseases IgG4-related disease and systemic sclerosis
Abstract Poster Presenter: Laura Yockey, MD, PhD – MGH
10:30 AM - 12:30 PM Central Time

GNTI-350: A CAR-Treg Therapy Offering Durable Immune Reset with Improved Safety for B Cell–Driven Autoimmune Diseases
Abstract Poster Presenter: Christopher Moore, PhD – GentiBio
10:30 AM - 12:30 PM Central Time

Human MAIT cell produce IL-17 independently of IL-23 and TL1A
Abstract Poster Presenter: Kevin Hsu, PhD – AstraZeneca
10:30 AM - 12:30 PM Central Time

Identification of Novel HLA Class II–Restricted Autoantigens in Scleroderma and Ulcerative Colitis Using TargetScan 
Abstract Poster Presenter: Olivia Pryor, n/a – TScan Therapeutics
10:30 AM - 12:30 PM Central Time

IL-17A+ HLA-DR-CCR6+ regulatory T cells: Dual role in T cell suppression and synovial inflammation in arthritis.
Abstract Poster Presenter: Bennie Heeswijk, MSc (he/him/his) – Erasmus University Medical Center, Rotterdam, the Netherlands
10:30 AM - 12:30 PM Central Time

IL-23 upregulates IFN-γ secretion in Th17.1, but not in Th17 or classical Th1 cells
Abstract Poster Presenter: Bennie van Heeswijk, MSc (he/him/his) – Erasmus MC, University Medical Center Rotterdam
10:30 AM - 12:30 PM Central Time

Impact of Immunosuppressive Therapies on Shingrix Vaccine Response in Immune-Mediated Inflammatory Diseases
Abstract Poster Presenter: Cristiana Sieiro Santos, MD – Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
10:30 AM - 12:30 PM Central Time

Interleukin-21 as a driver of CD8 T cell tissue resident memory and pathogenesis in dermatomyositis
Abstract Poster Presenter: Heather Ren, MD, PhD – Children's Hospital of Pittsburgh
10:30 AM - 12:30 PM Central Time

LBL-053, A Novel Anti-TL1A/p40 Bispecific Antibody for the Treatment of Autoimmune Disorders.
Abstract Poster Presenter: Hong Ling, n/a – Nanjing Leads Biolabs Co., Ltd.
10:30 AM - 12:30 PM Central Time

LBL-057, a Novel ADCC Enhanced PD-1 Agonist VHH-Fc Antibody
Abstract Poster Presenter: Xiao Huang, MS – Leads Biolabs
10:30 AM - 12:30 PM Central Time

Lupus Skin Shapes a Distinct Inflammatory Milieu that Drives the Skewing of Treg and inflammatory T cells
Abstract Poster Presenter: Hiroshi Kato, MD (he/him/his) – Michigan Medicine
10:30 AM - 12:30 PM Central Time

MTHFD2 is a Novel Metabolic Target in Autoimmune Disease
Abstract Poster Presenter: Laura McMillan – Sitryx Therapeutics
10:30 AM - 12:30 PM Central Time

Myositis Induced by Histidyl-Transfer tRNA Synthetase is Exacerbated by Membranopathy and Suppressed by Regulatory T Cells
Abstract Poster Presenter: Samantha Coss, MD, PhD (she/her/hers) – Nationwide Children's Hospital
10:30 AM - 12:30 PM Central Time

NOD2 mutations mediate IL-17 predisposition in patients with Blau syndrome
Abstract Poster Presenter: Leah Huey, BS – Oregon Health & Science University
10:30 AM - 12:30 PM Central Time

Potent Engineering of Polyfunctional CD8+ T Cells by a Novel In Vivo CAR mRNA Product Candidate (CPTX2309) in a Targeted Lipid Nanoparticle (tLNP) Utilizing CellSeeker^TM Technology
Abstract Poster Presenter: Yan Zhang, PhD – Capstan Therapeutics
10:30 AM - 12:30 PM Central Time

Preclinical Characterization of a Novel Bi-specific Antibody Targeting IL-23p19 and IL-36R for The Treatment of Autoimmune Diseases
Abstract Poster Presenter: Qianqian Yin, PhD (she/her/hers) – Jiangsu Hengrui Pharmaceuticals Co., Ltd.
10:30 AM - 12:30 PM Central Time

Resident Memory T Cells Stimulate Pathogenic Activity in Fibroblast-like Synoviocytes
Abstract Poster Presenter: Madison Mangin, BS – Boston Children's Hospital
10:30 AM - 12:30 PM Central Time

S-4321, a novel dual-cell bifunctional PD-1:FcγRIIb selective agonist antibody for autoimmune disease, maintains expression of PD-1 on target cells and enhances inhibitory receptor expression on T cells in vivo
Abstract Poster Presenter: Julia Manasson, MD, MS – Seismic Therapeutic
10:30 AM - 12:30 PM Central Time

Single-Cell Analysis Reveals Tissue Resident Memory T Cells Heterogeneity in the Joint
Abstract Poster Presenter: Yang Yang, PhD – Boston Children's Hospital
10:30 AM - 12:30 PM Central Time

UTAA91: An Off-the-Shelf Allogeneic CAR-Vδ1T Therapy Leveraging CD19 Nanoantibody for B-cell Depletion and PD-1 Agonist Nanoantibody for Pathogenic T-cell Elimination in Refractory Autoimmune Diseases
Abstract Poster Presenter: Lin Yang, PhD – PersonGen BioTherapeutics(Suzhou) Co., Ltd., Suzhou, China; PersonGenAnke Cellular Therapeutics Co., Ltd.,Hefei, China; Cyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China