(0955–0977) Systemic Sclerosis & Related Disorders – Basic Science Poster I

Monday, October 27, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

A Single-cell Atlas Reveals Dermal Endothelial Heterogeneity and Disease-specific Pathways in Autoimmune Disorders
Abstract Poster Presenter: Jinyi Qian, -None- – Shanghai Jiao Tong University School of Medicine
10:30 AM - 12:30 PM Central Time

Asynchronous Resolution of Inflammation and Fibrosis in a Prolonged Experimental Model Suggests Distinct Temporal Dynamics and Resolution Mechanisms in Systemic Sclerosis
Abstract Poster Presenter: Aurore Collet, PhD – University of Lille
10:30 AM - 12:30 PM Central Time

Effects of a Novel Hybrid Protein Based on S100 on Macrophage Polarization and Its Therapeutic Efficacy in a Bleomycin-Induced Systemic Sclerosis Mouse Model.
Abstract Poster Presenter: Takuya Kotani, MD, PhD – Osaka Medical and Pharmaceutical University
10:30 AM - 12:30 PM Central Time

FOXO1 Mediated Polysialic Acid Dysregulation in Severe Systemic Sclerosis (SSc): A Novel Biomarker and Therapeutic Target?
Abstract Poster Presenter: Mohammed Osman, MD, PhD, BSc – University of Alberta
10:30 AM - 12:30 PM Central Time

Genomic instability in systemic sclerosis is promoted by metabolic remodelling via a FOXO1-dependent axis
Abstract Poster Presenter: Mohammed Osman, MD, PhD, BSc – University of Alberta
10:30 AM - 12:30 PM Central Time

Inhibition of Nicotinamide N-Methyltransferase Reverses Fibroblast Activation via Epigenetic and Metabolic Remodeling in Systemic Sclerosis
Abstract Poster Presenter: Kamal Saba, PhD (he/him/his) – University of Michigan
10:30 AM - 12:30 PM Central Time

Integrated Bulk and Single Cell Analysis Confirms Differential Upregulation of the Proton Sensing Receptor GPR68 in Systemic Sclerosis Across Disease Stage and Subset
Abstract Poster Presenter: Kristina Clark, PhD, MBBS, MRCP – University of Oxford
10:30 AM - 12:30 PM Central Time

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation
Abstract Poster Presenter: Xuezhi Hong, MD – Department of Rheumatology, University Hospital Dusseldorf, Medical Faculty of Heinrich Heine University, Dusseldorf, Germany
10:30 AM - 12:30 PM Central Time

LMPTP Drives Fibrosis in Systemic Sclerosis via TGF-beta Signaling Activation
Abstract Poster Presenter: Yuan Zhan, n/a (she/her/hers) – Cedars-Sinai Medical Center
10:30 AM - 12:30 PM Central Time

Longitudinal Multiomic Study of Skin, Peripheral Blood, and Serum: Serum Proteome Reflects the Disease Process at the End-organ Level and Predicts the Course of Modified Rodnan Skin Score
Abstract Poster Presenter: Bich Na Choi, PhD – UT Health Houston
10:30 AM - 12:30 PM Central Time

Mapping Metabolic Changes in Skin Fibrosis in Systemic Sclerosis by Spatial Proteomics
Abstract Poster Presenter: Alexandru-Emil Matei, -None- – University Hospital Düsseldorf
10:30 AM - 12:30 PM Central Time

Mesenchymal Stromal Cells in Systemic Sclerosis are Dysfunctional and Have a Profibrotic and Senescent Phenotype
Abstract Poster Presenter: Marianela Brizio, MD, MSc (she/her/hers) – McGill University
10:30 AM - 12:30 PM Central Time

Multi-Omic Profiling Reveals a Monocyte-Vascular Signature Associated with the Regression of Skin Fibrosis in SSc
Abstract Poster Presenter: Astrid Hofman, MSc – Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich
10:30 AM - 12:30 PM Central Time

Pharmaceutical Blockade of the Neonatal Fc Gamma Receptor Ameliorates Autoimmunity, Inflammation and Fibrosis in the Topoisomerase I Mouse Model of Systemic Sclerosis
Abstract Poster Presenter: Cuong Tran Manh, PhD (he/him/his) – Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University.
10:30 AM - 12:30 PM Central Time

Prominent endothelial senescence in systemic sclerosis skin
Abstract Poster Presenter: Eliza Pei-Suen Tsou, PhD (she/her/hers) – University of Michigan
10:30 AM - 12:30 PM Central Time

Retinoic acid-related orphan receptor-α: A novel upstream regulator of Hippo signaling and potential therapeutic target in fibrosis
Abstract Poster Presenter: Cuong Tran Manh, PhD (he/him/his) – Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University.
10:30 AM - 12:30 PM Central Time

Single-Cell RNA Sequencing Reveals a Prominent Pro-Inflammatory Gene Signature of Dermal Fibroblasts in Pre-Stages of SSc
Abstract Poster Presenter: Lumeng Li, MMSc – University Hospital Zurich, University of Zurich
10:30 AM - 12:30 PM Central Time

Spatial Proteomics Analysis of the organization of tertiary lymphoid structures in Systemic Sclerosis Skin
Abstract Poster Presenter: Dennis Bleck, PhD (he/him/his) – University Hospital Düsseldorf, Department of Rheumatology, Hiller Research Center
10:30 AM - 12:30 PM Central Time

Surveying RNA methylation in scleroderma highlights roles for demethylases ALKBH5 and FTO in fibrosis
Abstract Poster Presenter: Alexander Cai, BS – University of Michigan
10:30 AM - 12:30 PM Central Time

The nuclear receptor DAX1 regulates WNT/β-catenin signaling to promote fibroblast activation and skin fibrosis in systemic sclerosis
Abstract Poster Presenter: Yun Zhang, PhD – University Hospital Erlangen
10:30 AM - 12:30 PM Central Time

Tissue resident macrophages derived from induced pluripotent stem cells induce tissue fibrosis in human skin equivalent models of systemic sclerosis
Abstract Poster Presenter: Xuezhi Hong, MD – Department of Rheumatology, University Hospital Dusseldorf, Medical Faculty of Heinrich Heine University, Dusseldorf, Germany
10:30 AM - 12:30 PM Central Time

Unraveling the role of the hippo pathway in systemic sclerosis: A focus on TEADs and VGLL3
Abstract Poster Presenter: Neha Khanna, -None- – University of Michigan
10:30 AM - 12:30 PM Central Time

Increased expression of M2 pro-fibrotic markers in circulating monocytes and cultured monocyte-derived macrophages from systemic sclerosis patients with progressive interstitial lung disease (ILD)
Abstract Poster Presenter: Emanuele Gotelli, MD, PhD – Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialties (Di.M.I.), University of Genova