(0916–0933) Innate Immunity Poster

Monday, October 27, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

Discovery and Characterization of SIM0711: a Potent and Selective IRAK4 PROTAC with Improved Efficacy and Safety
Abstract Poster Presenter: Minyun Zhou, PhD – Simcere Pharmaceutical Group
10:30 AM - 12:30 PM Central Time

Human Serum Albumin Co-Modified with Malondialdehyde-Acetaldehyde and Citrulline Bind Multiple Scavenger Receptors and Alter Cellular Morphology
Abstract Poster Presenter: Lauren Klingemann, BS – University of Nebraska Medical Center
10:30 AM - 12:30 PM Central Time

Functional Characterization of NEMO-NDAS Causing Variants in Patients’ PBMCs and in Wildtype and Mutant U937 Cells
Abstract Poster Presenter: Elizabeth Morgan, BS – Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH
10:30 AM - 12:30 PM Central Time

SP2H, a Targeted Degrader of STimulator of INterferon Genes (STING), selectively inhibits STING-driven inflammation in vitro and in vivo and improves survival in Trex1^-/- mice
Abstract Poster Presenter: Richard BETHELL, PhD, MA (he/him/his) – Sulis Therapeutics
10:30 AM - 12:30 PM Central Time

UVB-Irradiated Keratinocyte Extracellular Vesicles Trigger Innate Immune Activation via Type I Interferons and STING Pathway
Abstract Poster Presenter: Ahmed Eldaboush, MD – University of Pennsylvania
10:30 AM - 12:30 PM Central Time

Phenotypic and Transcriptomic Divergence in C3 Glomerular Mouse Models: Insights into Immune and Sex Correlates
Abstract Poster Presenter: Juan Liang, DrPH – Gempharmatech
10:30 AM - 12:30 PM Central Time

Influenza Virus Infection Alters the MHC Class II Self-Immunopeptidome to Present Lupus-Associated Autoantigens
Abstract Poster Presenter: Julia Rood, MD, PhD – Children's Hospital of Philadelphia
10:30 AM - 12:30 PM Central Time

Improved Skin Lymphatic Flow Regulates Dendritic Cells to Mediate Lymph Node Fibroblast Alterations and Immune Responses in Lupus
Abstract Poster Presenter: Mir Howlader, BA – Weill Cornell Medicine
10:30 AM - 12:30 PM Central Time

Reduced mitophagy in salivary glands of Sjögren's disease patients is associated with mitochondrial structural damage
Abstract Poster Presenter: Sergio Aguilera, MD – Clinica Indisa
10:30 AM - 12:30 PM Central Time

Spatial Transcriptomics Reveal Altered Immune Dynamics Regulating Placental Development In a Humanized-TLR8 Mouse Model of Spontaneous Anti-Phospholipid Antibody Induced Pregnancy Loss
Abstract Poster Presenter: Yunwei Xia, BA – Feinstein Institutes for Medical Research
10:30 AM - 12:30 PM Central Time

Potent and Selective Oral IRF5 Degrader, KT 579, Blocks Pro-Inflammatory Cytokines and Reduces Joint Swelling in a Mouse Model of Rheumatoid Arthritis
Abstract Poster Presenter: Ryan Camire, PhD – Kymera Therapeutics
10:30 AM - 12:30 PM Central Time

Radiolabelled anti-citrullinated histone antibody CIT-013 as a tool to visualize NET rich inflamed joints in a collagen induced arthritic mouse model
Abstract Poster Presenter: Renato Chirivi, PhD, MSc – Citryll BV
10:30 AM - 12:30 PM Central Time

Retention of variant forms of TNFR1 in the Golgi induces stress responses and monocyte activation in systemic Juvenile Idiopathic Arthritis (sJIA)
Abstract Poster Presenter: Anthony Cruz, BS – National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH
10:30 AM - 12:30 PM Central Time

Compartment-specific NK-cell phenotypes reveal distinct maturation and activation states in inflammatory arthritis
Abstract Poster Presenter: Wolfgang Merkt, MD – University Hospital Düsseldorf
10:30 AM - 12:30 PM Central Time

Pathogenic role of SPP1+ macrophages in Rheumatoid Arthritis
Abstract Poster Presenter: Megan M. Hanlon, PhD, BSc (she/her/hers) – Brigham and Women's Hospital, HMS
10:30 AM - 12:30 PM Central Time

Synovial Tissue Neutrophils are Associated with Disease Activity and Early Remission in Rheumatoid Arthritis
Abstract Poster Presenter: Annabelle Small, PhD, BSc – Flinders University
10:30 AM - 12:30 PM Central Time

Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns
Abstract Poster Presenter: Diego Kyburz, MD (he/him/his) – University Hospital Basel
10:30 AM - 12:30 PM Central Time

Fibrinogen Co-Modified with Malondialdehyde-Acetaldehyde and Citrulline Promotes Pro-Inflammatory Macrophage Differentiation Through p38 and NF-κB Signaling
Abstract Poster Presenter: Hannah Johnson, BS – University of Nebraska Medical Center