(0897–0915) B Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster II

Monday, October 27, 2025

10:30 AM - 12:30 PM Central Time

Location: Hall F1

CE: 0.00

Presentations:

10:30 AM - 12:30 PM Central Time

Preclinical Expansion of Autoreactive Naive B cells Drives RA onset in ACPA+ individuals
Abstract Poster Presenter: Xiaohao Wu, PhD – Stanford University
10:30 AM - 12:30 PM Central Time

Altered B Cell Subsets Shared in Immune Checkpoint Inhibitor Associated Sicca Syndrome and Sjogren's Disease
Abstract Poster Presenter: Caroline Atlas, MD (she/her/hers) – Columbia University
10:30 AM - 12:30 PM Central Time

A Novel Fcrn × Albumin Bispecific Antibody Demonstrates Extended Half-life And deep Igg Reduction in Preclinical Mouse Models
Abstract Poster Presenter: Quan Yu, PhD – Ailux
10:30 AM - 12:30 PM Central Time

Data-Driven Metabolomics Identifies Diagnostic Signatures and Patient Subgroups in Systemic Autoimmune Disorders
Abstract Poster Presenter: Chary Lopez-Pedrera, PhD – IMIBIC - Reina Sofia Hospital
10:30 AM - 12:30 PM Central Time

APECED Disease Reorganizes the B Cell Compartment Toward Alternatively Activated Subsets
Abstract Poster Presenter: Andre Limnander, PhD – Regeneron
10:30 AM - 12:30 PM Central Time

Distinct B Cell and Plasma Cell Immunosuppression Strategies Eliminate Antigen-Specific Cells of the B Lineage
Abstract Poster Presenter: Carley Tasker, PhD – Regeneron Pharmaceuticals
10:30 AM - 12:30 PM Central Time

Potent and Selective Oral IRF5 Degrader, KT-579, Demonstrates In Vitro and In Vivo Activity Comparable or Superior to Approved or Clinically Active Agents in Human Cellular Assays and Lupus Efficacy Models
Abstract Poster Presenter: Veronica Campbell, BSc – Kymera Therapeutics
10:30 AM - 12:30 PM Central Time

Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice.
Abstract Poster Presenter: Marcus Hines, MD;PhD – New York University Grossman School of Medicine
10:30 AM - 12:30 PM Central Time

Ianalumab‘s dual mode of action: targeting B cells through enhanced B cell depletion and blockade of B cell-activating factor receptor signaling
Abstract Poster Presenter: Isabelle Isnardi, PhD – Novartis
10:30 AM - 12:30 PM Central Time

E-602 (Efgitasialase alfa) Enhances Memory B Cell Depletion and Reduces Profibrotic Macrophages via Desialylation in Autoimmune Disease
Abstract Poster Presenter: Li Peng, PhD – Palleon Pharmaceuticals
10:30 AM - 12:30 PM Central Time

A Novel Approach to Study ANA+ B Cells in Lupus Integrating Flow Cytometry with Single-cell Culture
Abstract Poster Presenter: Muriel Velez Arteaga, MD (she/her/hers) – The Elmezzi School of Molecular Medicine
10:30 AM - 12:30 PM Central Time

Development of Four Distinct Human IgG4-Producing Mouse Models Recapitulating IgG4-Related Disease
Abstract Poster Presenter: Min-Gang Kim, PhD – Seoul National University College of Medicine
10:30 AM - 12:30 PM Central Time

Preclinical Characterization of IBI3034, an TACI and BCMA Chimeric Fc Fusion Protein, that Potently Modulates B Lymphocytes and Serum Immunoglobulin for the Treatment of B cell Related Autoimmune Disease
Abstract Poster Presenter: Jinyang Li, PhD (he/him/his) – Innovent Biologics (Suzhou) Co., Ltd.
10:30 AM - 12:30 PM Central Time

Cross-Species Cellular Mapping and Humanization of Fcγ Receptors to Advance Antibody Modeling
Abstract Poster Presenter: Karel Van Damme, MD, PhD – Ghent University Hospital
10:30 AM - 12:30 PM Central Time

SLAMF7 Drives Plasma Cell Differentiation in Rheumatoid Arthritis Synovium.
Abstract Poster Presenter: Jabea Cyril Ekabe, MD, MS (he/him/his) – University of Rochester
10:30 AM - 12:30 PM Central Time

A Fusion of TACI Variant and Anti-ifnar Antibody with Greater Therapeutic Effect on Related Autoimmune Disease Models
Abstract Poster Presenter: Yuhao Qin, n/a (he/him/his) – Jiangsu Hengrui Pharmaceuticals Co., Ltd
10:30 AM - 12:30 PM Central Time

WITHDRAWN
10:30 AM - 12:30 PM Central Time

CD11c⁺CD21⁻ Autoimmune-Associated B Cells Derived from Double-Negative IgD⁻CD27⁻ Subsets Exhibit Enhanced IFNLR1 Expression in Systemic Lupus Erythematosus
Abstract Poster Presenter: ROUKAYA YAAKOUBI, PhD (she/her/hers) – University of Rochester