Energizing Immunity: How Mitochondria Contribute to Inflammation in Lupus and Photosensitivity

Sunday, October 26, 2025

9:00 AM - 10:00 AM Central Time

CE: 1

Moderator(s)

CL

Christian Lood, PhD

University of Washington
Seattle, WA, United States

Disclosure(s): Amytryx: Grant/Research Support (Terminated, August 1, 2023); Boehringer Ingelheim: Grant/Research Support (Ongoing); Citryll: Consultant (Ongoing); Eli Lilly: Grant/Research Support (Terminated, April 1, 2023); Exagen: Consultant (Ongoing); Gilead Sciences: Grant/Research Support (Terminated, December 31, 2023); Pfizer: Grant/Research Support (Terminated, December 31, 2023); Redd Pharma: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Grant/Research Support (Ongoing)
RM

Richard Moore, BSc (he/him/his)

Cedars-Sinai
Beverly Hills, CA, United States

Disclosure(s): No financial relationships with ineligible companies to disclose

Session Coordinator(s)

CL

Christian Lood, PhD

University of Washington
Seattle, WA, United States

Disclosure(s): Amytryx: Grant/Research Support (Terminated, August 1, 2023); Boehringer Ingelheim: Grant/Research Support (Ongoing); Citryll: Consultant (Ongoing); Eli Lilly: Grant/Research Support (Terminated, April 1, 2023); Exagen: Consultant (Ongoing); Gilead Sciences: Grant/Research Support (Terminated, December 31, 2023); Pfizer: Grant/Research Support (Terminated, December 31, 2023); Redd Pharma: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Grant/Research Support (Ongoing)

Mitochondria have emerged as much more than energy-providing organelles, being implicated also in regulation of cell death, inflammation, and oxidative stress. In this session, we will highlight recent findings where mitochondria promote inflammation and autoimmunity in rheumatic disease.

Learning Objectives:

Recall the various functions mitochondria partake in to regulate homeostasis
Describe how mitochondrial RNA and DNA may be sensed and cause inflammation and autoimmunity
List sources of extracellular mitochondria in autoimmune conditions

Presentations:

9:00 AM - 9:30 AM Central Time

Ultraviolet-Mediated Damage to Mitochondria in Systemic Lupus Erythematosus
Speaker: J. Michelle Kahlenberg, MD, PhD – University of Michigan
9:30 AM - 10:00 AM Central Time

Erythrocytes Carrying More Power Than Expected
Speaker: Simone Caielli, PhD – weill cornell medicine