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Final Program


Schedule at a Glance
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Program: Scientific Session
General Topic: Basic Science

Driving CAR-T into the Future: What Are the Right B Cell Targets in Systemic Lupus Erythematosus and Beyond?

Sunday, October 26, 2025
10:30 AM – 11:30 AM Central Time

    Moderator(s)

  • Anne Davidson, MBBS, FRACP

    Feinstein Institutes for Medical Research
    Manhasset, New York, United States

    Disclosure(s): Amgen: Advisor or Review Panel Member (Terminated); Bristol Myers Squibb: Advisor or Review Panel Member (Terminated)

    • Session Coordinator(s)

  • JT

    Jeremy Tilstra, MD, PhD

    University of Pittsburgh
    Pittsburgh, Pennsylvania, United States

    Disclosure(s): Souffle theraputics: Consultant (Ongoing)

    • Interactive Moderator(s)

  • JT

    Jeremy Tilstra, MD, PhD

    University of Pittsburgh
    Pittsburgh, Pennsylvania, United States

    Disclosure(s): Souffle theraputics: Consultant (Ongoing)

B cells are incredibly important in the pathogenesis of connective tissue diseases, and our strategies for depleting them have expanded recently with the advent of cellular therapy. However, global humoral suppression is the "tip of the iceberg". This session will help to explain which B cell subsets are pathologic in autoimmunity and engage the audience in discussions about how to selectively target them.

Learning Objectives:

  • Demonstrate that various B cell subsets are pathologic in autoimmunity
  • Discuss B cell profiles that distinguish autoreactive from non-autoreactive responses
  • Examine novel pathways and targets that might promote the selective targeting of autoreactive B cells in autoimmune disease

Presentations:

  • 10:30 AM – 11:30 AM Central Time
    Panel Discussion

    Panelist: Nan Shen, MD, PhD – Shanghai Jiang Tong University School of Medicine

    Panelist: Iñaki Sanz, MD – Emory University School of Medicine