Julia Charles, MD, PhD
Brigham and Women's Hospital
Boston, Massachusetts, United States
Disclosure(s): Alexion: Advisor or Review Panel Member (Ongoing), Grant/Research Support (Ongoing); Kyowa Kirin: Advisor or Review Panel Member (Terminated, October 31, 2023)
Baohong Zhao, MD, PhD
Hospital for Special Surgery
New York, New York, United States
Disclosure information not submitted.
Baohong Zhao, MD, PhD
Hospital for Special Surgery
New York, New York, United States
Disclosure information not submitted.
Osteoporosis is the most prevalent bone disease worldwide and a significant public health concern. In the United States, approximately 10 million individuals aged 50 and older are affected by osteoporosis, with an additional 44 million having low bone density, increasing their risk. The underlying mechanisms of osteoporosis are largely unknown. This session will highlight novel discoveries in bone metabolisms in osteoporosis. Dr. Thomas H. Ambrosi will discuss a maternal brain hormone that plays a key role in building bone. Dr. Fabrisia Ambrosio will discuss the menopause-induced 17β-estradiol and progesterone loss that increases senescence markers, matrix disassembly, and degeneration in cartilage. Dr. Sundeep Khosla will discuss the effects of intermittent senolytic therapy on bone metabolism in postmenopausal women.
Speaker: Thomas Ambrosi�, PhD – UC Davis Health
Speaker: Fabrisia Ambrosio, PhD – Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding, Boston, MA, USA.
Speaker: Sundeep Khosla, MD – Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, MN, USA.
