Beyond NETs: Alternative Roles of Neutrophils in Spondyloarthritis

Moderator(s)

• IA

  Iannis Adamopoulos, PhD

  Harvard Medical School, BIDMC, Division of Rheumatology
  Boston, Massachusetts, United States

  Disclosure(s): No financial relationships with ineligible companies to disclose

Session Coordinator(s)

• CL

  Christian Lood, PhD

  University of Washington
  Seattle, WA, United States

  Disclosure information not submitted.

Over the last few years, there have been new emerging paradigms of axial spondyloarthritis (axSpA) pathobiology involving neutrophils. This includes a causative role in onset of disease and propagation of pathogenic T helper 17 (Th17) responses, as well as a putative explanation of entheseal involvement and spinal disease in patients with a more prolonged course. These findings have been extended in outcomes studies, where neutrophil markers track with human disease manifestations, including measure of disease activity and presences of sacroiliitis.

Join us for an innovative session that synergizes the clinical perspective with mechanistic studies in experimental axSpA and human neutrophils.

Presentations:

• 1:00 PM – 1:30 PM Central Time

  Role of Neutrophil Interleukin-23 in Spondyloarthropathy Spectrum Disorders
  

  Speaker: Dennis McGonagle, MD, PhD – Uni of Leeds
• 1:30 PM – 2:00 PM Central Time

  HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model
  

  Speaker: Nigil Haroon, MD, PhD, DM, FRCPC, FRCP, MBA – University Health Network